Hydroxyapatite (HAp) yog calcium phosphate zoo ib yam li tib neeg cov ntaub so ntswg tawv hauv morphology thiab muaj pes tsawg leeg.1. Tshwj xeeb, nws muaj cov qauv hexagonal2, 3thiab stoichiometric Ca/P piv ntawm 1.67, uas zoo tib yam rau pob txha apatite2, 4, 5.
Ib tug yam ntxwv tseem ceeb ntawm hydroxyapatite yog nws cov stability thaum piv rau lwm cov calcium phosphates. Thermodynamically, hydroxyapatite yog qhov ruaj khov tshaj plaws calcium phosphate compound nyob rau hauv physiological tej yam kev mob raws li kub, pH thiab muaj pes tsawg leeg ntawm lub cev kua.2.
Nrog rau txoj kev loj hlob ntawm nanotechnology, ib qho kev cuam tshuam loj ntawm cov ntaub ntawv tshawb fawb tau pom. Kev tsim cov nanomaterials tau txais kev saib xyuas ntau rau adsorption, catalysis thiab optical applications, tshwj xeeb tshaj yog thaum biomaterials koom nrog.6.
Nano-hydroxyapatite (nano-HAp) tau ntxim nyiam ua cov khoom siv biomaterial rau kev siv cov khoom siv dag zog vim nws qhov zoo sib xws ntawm qhov loj me, crystallography thiab tshuaj muaj pes tsawg leeg nrog tib neeg cov ntaub so ntswg. Pob txha thiab cov hniav enamel feem ntau yog tsim los ntawm ib daim ntawv ntawm cov pob zeb no.
Vim nws cov khoom zoo heev6:
· Biocompatibility
· Bioactivity
· Osteoconductivity
· Tsis muaj toxicity thiab tsis inflammatory xwm
Cov nano-hydroxyapatite bioceramic tau txais ntau yam kev siv uas suav nrog6:
· Pob txha Engineering
· Pob txha void fillers rau orthopaedic, traumatology, txha nraub qaum, maxillofacial thiab kho hniav phais.
· Orthopedic thiab kho hniav implant txheej
· Restoration ntawm periodontal defects
· Edentulous ridge augmentation
· Endodontic kev kho mob zoo li pulp capping
· Kho cov neeg kho tshuab furcation perforations thiab apical barrier tsim
· Fillers rau reinforcing restorative iav ionomer MAAs (GIC) thiab restorative composite resin
· Desensitizing tus neeg sawv cev nyob rau hauv post hniav bleaching
· Remineralizing tus neeg sawv cev hauv cov tshuaj txhuam hniav
· Kev kho mob thaum ntxov carious
· Kev xa tshuaj thiab noob
Cov ntaub ntawv tshuaj xyuas qhia tau hais tias qhov kev pheej hmoo cuam tshuam nrog kev nthuav tawm rau nanopticulate calcium phosphate hauv cov koob tshuaj uas feem ntau siv rau hauv biomedicine, cov khoom kho mob thiab tshuaj pleev ib ce muaj tsawg heev thiab feem ntau yuav tsis tshwm sim. Ntxiv mus, nws kuj tau hais tias nyob rau hauv txhua yam tsim nyog, calcium phosphate nanoparticles tuaj yeem suav tias yog kev nyab xeeb rau tib neeg.7.
|
IUPAC npe |
Pentacalcium hydroxide triphosphate |
|
CAS nr |
12167-74-7 |
|
EC tus lej |
235-330-6 |
|
Synonyms |
Hydroxyapatite (CAS n.1306-06-5), Hydroxylapatite, Calcium hydroxyapatite |
|
Tshuaj formula |
Ca10(PO4)6(OH)2 |
|
Molecular hnyav |
1004.6 g / mol |
------ Kev Siv Kho Mob ------
Titanium thiab stainless hlau implants feem ntau yog them nrog hydroxyapatite coatings los ntxias lub cev thiab txo qhov kev cog lus rejection tus nqi. Hydroxyapatite kuj tseem siv tau rau hauv cov xwm txheej uas muaj pob txha pob txha lossis qhov tsis xws luag. Cov txheej txheem no yog ua los ntawm cov hmoov, blocks lossis hlaws dai ntawm cov khoom uas tau muab tso rau hauv qhov chaw cuam tshuam ntawm cov pob txha.
Vim nws bioactivity, nws txhawb cov pob txha kom loj hlob thiab kho qhov tsis xws luag. Cov txheej txheem no tuaj yeem yog lwm txoj hauv kev rau cov pob txha allogenic thiab xenogenic grafts. Nws feem ntau ua rau lub sijhawm kho mob luv dua li cov uas tau pom yog tias tsis siv hydroxyapatite.
------ Kev Kho Hniav Qhov ncauj ------
Enamel muaj pes tsawg leeg yog 97 wt.% nano-hydroxyapatite thiab 3 wt.% organic khoom thiab dej. Hauv dentin, nano-hydroxyapatite sawv cev rau 70 wt.%8.
Raws li Nano-hydroxyapatite yog cov khoom tseem ceeb ntawm cov enamel, nws muab cov tsos ntawm cov xim dawb thiab tshem tawm cov diffuse reflectivity ntawm lub teeb los ntawm kev kaw cov pores me me ntawm cov enamel nto.
Synthetic nano-hydroxyapatite ua raws li qhov loj ntawm cov hniav dentinal hydroxyapatite lossis enamel apatite. Cov txiaj ntsig kev sim qhia pom qhov zoo ntawm nano-hydroxyapatite hauv kev kho cov enamel9-10, uas tau ua rau nws koom nrog hauv cov tshuaj txhuam hniav thiab cov tshuaj ntxuav qhov ncauj los txhawb kev kho cov demineralized enamel los yog dentin nto los ntawm depositing hydroxyapatite nanoparticles nyob rau hauv qhov tsis xws luag.11.
------ Lwm Cheeb Tsam ------
Kev sim nanostructured composite cua lim uas muaj hydroxyapatite tau pom tias muaj txiaj ntsig zoo hauv kev nqus thiab decomposing CO, uas tuaj yeem ua rau nws siv los txo cov pa phem hauv tsheb.12.
Hauv xyoo 2014, alginate / nano-hydroxyapatite sib xyaw tau raug tsim thiab sim teb raws li cov tshuaj adsorbent rau fluoride. Qhov biocomposite no tshem tawm cov tshuaj fluoride los ntawm kev sib pauv ion thiab yog ob qho tib si biocompatible thiab biodegradable.13.
Tsis ntev los no, kev siv hauv catalysis14-16thiab kev sib cais ntawm cov protein17tau tsim thiab ua tiav kev sim siv nanostructured calcium phosphates, uas qhia tias muaj ntau yam kev siv tshiab rau cov ntaub ntawv no tseem tsis tau tuaj.
Hydroxyapatite (electron microscope duab)
1. Nano nplai (koob hom)
2. Micron nplai (spherical)
3. Micron theem (koob hom)
3. Micron theem (qhib pas nrig)
